Starting Point: You Are Starting From Tampa, Fl. Head Northeast On I-275 N: Take The Interstate 275 North Ramp To Ocala. Merge Onto I-275 N: Continue On I-275 N For About 6.2 Miles. Use The Right 2 Lanes To Take Exit 51 For I-4 E Toward Orlando: Merge Onto I-4 E. Keep Left To Stay On I-4 E: Continue On I-4 E For Approximately 6.8 Miles. Take Exit 9 For Us-41 N/Us-92 E Toward 21St St: Keep Left At The Fork, Follow Signs For U.S. 41 N/U.S. 92 E.